Otx2's Incredible Journey

Hypotheses concerning how Otx2 makes its incredible journey: a hitchhiker on the road to Rome?

INTRODUCTION From work carried out largely by Alain Prochiantz and his co-workers at the College de France (Sugiyama et al., 2008; Beurdeley et al., 2012; Carlier et al., 2013; Smythies and Edelstein, 2013; Spatazza et al., 2013a,b), it is now known that the homeoprotein and transcription factor molecule Otx2 possesses a very unusual property. This flexible molecule is able to cross cell membra...

Incredible journey through the digestive system.

No wonder you activities are, reading will be always needed. It is not only to fulfil the duties that you need to finish in deadline time. Reading will encourage your mind and thoughts. Of course, reading will greatly develop your experiences about everything. Reading incredible journey through the digestive system is also a way as one of the collective books that gives many advantages. The adv...

From Thebes to Toronto and the 21st Century: An Incredible Journey

Identification of otx2 target genes and restrictions in ectodermal competence during Xenopus cement gland formation.

The homeobox gene otx2 is a key regulator of positional identity in vertebrates, however its downstream target genes and mechanism of action are not known. We have analyzed otx2 function during formation of the Xenopus cement gland, an organ that expresses otx2. The cement gland forms at early neurula from extreme anterior ectoderm and corresponds to the chin primordium of mammals. Previous stu...

Otx2 expression and implications for olfactory imprinting in the anemonefish, Amphiprion percula

The otx2 gene encodes a transcription factor (OTX2) essential in the formation of the brain and sensory systems. Specifically, OTX2-positive cells are associated with axons in the olfactory system of mice and otx2 is upregulated in odour-exposed zebrafish, indicating a possible role in olfactory imprinting. In this study, otx2 was used as a candidate gene to investigate the molecular mechanisms...